Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry.

Virology - 1 Dec 2017

Nahabedian John, Sharma Amit, Kaczmarek Maryska E, Wilkerson Greg K, Sawyer Sara L, Overbaugh Julie

Abstract excerpt

Studying HIV-1 replication in the presence of functionally related proteins from different species has helped define host determinants of HIV-1 infection. Humans and owl monkeys, but not macaques, encode a CD4 receptor that permits entry of transmissible HIV-1 variants due to a single residue difference. However, little is known about whether divergent CCR5 receptor proteins act as determinants of host-range....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to CD4 Antigens
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Receptors, CCR5

Share to Virus Internalization

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 28972927
DOI: 10.1016/j.virol.2017.09.018
PMCID: PMC6191650

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Owl monkey CCR5 reveals synergism between CD4 and CCR5 in HIV-1 entry.PMID 28972927Read ↗

Identification of Owl Monkey CD4 Receptors Broadly Compatible with Early-Stage HIV-1 Isolates.Semantic proximity Read ↗

Frequent Substitution Polymorphisms in African Green Monkey CCR5 Cluster at Critical Sites for Infections by Simian Immunodeficiency Virus SIVagm, Implying Ancient Virus-Host CoevolutionSemantic proximity Read ↗

Identification of HIV-1 Envelope Mutations that Enhance Entry Using Macaque CD4 and CCR5Semantic proximity Read ↗

A species-specific amino acid difference in the macaque CD4 receptor restricts replication by global circulating HIV-1 variants representing viruses from recent infection.Semantic proximity Read ↗

Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry.Semantic proximity Read ↗

Species-specific changes in the CCR5 gene from African and Asian nonhuman primates.Semantic proximity Read ↗

CD4-independent binding of SIV gp120 to rhesus CCR5.Semantic proximity Read ↗

Phenotype variation in human immunodeficiency virus type 1 transmission and disease progression.Semantic proximity Read ↗

Intra- and interspecific variation of the CCR5 gene in higher primates.Semantic proximity Read ↗

Determination of co-receptor usage of HIV-1.Semantic proximity Read ↗

Cooperation of multiple CCR5 coreceptors is required for infections by human immunodeficiency virus type 1.Semantic proximity Read ↗

The Expanding Therapeutic Perspective of CCR5 BlockadeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.