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Article

The N-linked glycan g15 within the V3 loop of the HIV-1 external glycoprotein gp120 affects coreceptor usage, cellular tropism, and neutralization.

Virology - 5 Dec 2002

Polzer Svenja, Dittmar Matthias T, Schmitz Herbert, Schreiber Michael

Abstract excerpt

We have studied infectivity and neutralization of X4, R5, and R5X4 tropic HIV-1 mutants, which are lacking N-linked glycosylation sites for glycans g13, g14, g15, and g17 in the V3 loop region of gp120. X4-tropic NL4-3 mutants lacking combinations of g14/15 or g15/17 showed markedly higher infect...

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Share to Glycosylation
Share to HIV Envelope Protein gp120
Share to Leukocytes, Mononuclear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neutralization Tests

Share to Polysaccharides

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Tropism

Source

Identifiers

PMID: 12490404
DOI: 10.1006/viro.2002.1760

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12490404-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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