Article
An abundant proneurotensin polymorphism, 479A>G, and a test of its association with alcohol dependence in a Finnish population.
Alcoholism, clinical and experimental research - 1 Jun 2000
Vanakoski J, Mazzanti C, Naukkarinen H, Virkkunen M, Goldman D
Abstract excerpt
BACKGROUND: Neurotensin is a 13-amino acid neuropeptide that endogenously modulates dopamine release in the central nervous system. In substance dependence, the mesolimbic dopamine system has been postulated to be a central structure that mediates rewarding and reinforcing effects. Neurotensin receptors in the neurons of the ventral tegmental area facilitate dopamine release, making the neurotensin gene an...
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