Article
Circulating Proneurotensin Concentrations and Cardiovascular Disease Events in the Community: The Framingham Heart Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016
Januzzi James L, Lyass Asya, Liu Yuyin, Gaggin Hanna, Trebnick April, Maisel Alan S, D'Agostino Ralph B, Wang Thomas J, Massaro Joseph, Vasan Ramachandran S
Abstract excerpt
OBJECTIVE: Neurotensin is a peptide whose receptor (sortilin receptor 1) is linked to cardiovascular disease (CVD) development. We hypothesized concentrations of proneurotensin (stable profragment of neurotensin) would predict incident cardiovascular events in community-based subjects. APPROACH AND RESULTS: Blood samples from 3439 participants in the Framingham Heart Study (FHS) Offspring cohort (mean age 59.2...
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