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Article

Mutation screening of the 5-hydroxytryptamine7 receptor gene among Finnish alcoholics and controls.

Psychiatry research - 27 Feb 1998

Pesonen U, Koulu M, Bergen A, Eggert M, Naukkarinen H, Virkkunen M, Linnoila M, Goldman D

Abstract excerpt

Impaired central serotonin neurotransmission has been associated with increased aggression, impaired impulse control and diurnal activity rhythm disturbances among humans. Neuroanatomic distribution and pharmacological properties of the serotonin 5-HT7 receptor suggest that it may play a role in psychiatric disorders and in circadian rhythm regulation. In this study a point mutation causing proline279 --> leucine...

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Identifiers

PMID: 9707296
DOI: 10.1016/s0165-1781(98)00005-5

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