Article
Comparative sequencing of the proneurotensin gene and association studies in schizophrenia.
Molecular psychiatry - 1 Mar 2000
Austin J, Hoogendoorn B, Buckland P, Speight G, Cardno A, Bowen T, Williams N, Spurlock G, Sanders R, Jones L, Murphy K, McCarthy G, McGuffin P, Owen M J, O'Donovan M C
Abstract excerpt
Neurotensin (NT) is an endogenous tridecapetide1 cleaved from a precursor proneurotensin/ proneuromedin protein. NT localises within dopaminergic neurones in the mesocortical, mesolimbic and nigrostriatal systems1-3 and it is now clear that NT can selectively modulate dopaminergic neurotransmission.2-9 These anatomical and functional connections have led to the hypothesis that NT dysfunction might contribute to...
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