Article
BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma.
Leukemia - 1 Aug 2000
Bullinger L, Leupolt E, Schaffner C, Mertens D, Bentz M, Lichter P, Döhner H, Stilgenbauer S
Abstract excerpt
The BCL10 gene has recently been cloned from the 1p22 breakpoint of the translocation t(1 ;14)(p22;q32) observed in mucosa-associated lymphoid tissue (MALT) lymphoma. BCL10 was shown to be a proapoptotic-signaling gene encoding a protein that contains an amino-terminal caspase recruitment domain (CARD). Mutations within the BCL10 coding region resulting in truncated BCL10 proteins with loss of their proapoptotic...
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