Article
Association analysis of the 5-HT5A gene in depression, psychosis and antipsychotic response.
Neuroreport - 26 Jun 2000
Birkett J T, Arranz M J, Munro J, Osbourn S, Kerwin R W, Collier D A
Abstract excerpt
The serotonergic system is targeted by both antidepressants and atypical antipsychotic drugs such as clozapine. Genetic variation in the 5-HT5A gene might be involved in susceptibility to depression, the major psychoses or in influencing clinical response to treatment. To examine this hypothesis we genotyped two polymorphisms (-19G/C; 12A/T) in the human 5-HT5A receptor gene in a sample of 269 unrelated...
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