Article
Investigation of the human serotonin receptor gene HTR3B in bipolar affective and schizophrenic patients.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Nov 2004
Frank Bernd, Niesler Beate, Nöthen Markus M, Neidt Helge, Propping Peter, Bondy Brigitta, Rietschel Marcella, Maier Wolfgang, Albus Margot, Rappold Gudrun
Abstract excerpt
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) mediates a multitude of central nervous functions by activating 5-HT receptor subtypes. A dysfunction of serotonergic neurotransmission is considered to play a major role in the pathophysiology of complex neuropsychiatric disorders. In our study, a mutation screen of the serotonin receptor gene HTR3B was carried out to explore a putative contribution to...
Topics
- 5' Untranslated Regions
- Alleles
- Base Sequence
- Bipolar Disorder
- DNA
- DNA Mutational Analysis
- Family Health
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Molecular Sequence Data