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Article

Homeodomain position 54 specifies transcriptional versus translational control by Bicoid.

Molecular cell - 1 Feb 2000

Niessing D, Driever W, Sprenger F, Taubert H, Jäckle H, Rivera-Pomar R

Abstract excerpt

Bicoid (BCD), the anterior determinant of Drosophila, controls embryonic gene expression by transcriptional activation and translational repression. Both functions require the homeodomain (HD), which recognizes DNA motifs at target gene enhancers and a specific sequence interval in the 3' untranslated region of caudal (cad) mRNA. Here we show that the BCD HD is a nucleic acid-binding unit. Its helix III contains...

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PMID: 10882080
DOI: 10.1016/s1097-2765(00)80434-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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