Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.

Gene expression patterns : GEP - 1 Jul 2014

Weinberg Florian, Schulze Ekkehard, Fatouros Chronis, Schmidt Enrico, Baumeister Ralf, Brummer Tilman

Abstract excerpt

Rio kinases are atypical serine/threonine kinases that emerge as potential cooperation partners in Ras-driven tumors. In the current study, we performed an RNAi screen in Caenorhabditis elegans to identify suppressors of oncogenic Ras signaling. Aberrant Ras/Raf signaling in C. elegans leads to the formation of a multi-vulva (Muv) phenotype. We found that depletion of riok-1, the C. elegans orthologue of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Butadienes
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Enzyme Inhibitors

Share to Extracellular Signal-Regulated MAP Kinases

Share to Gene Expression Regulation, Enzymologic

Share to Gonads

Share to Nitriles

Source

Identifiers

PMID: 24929033
DOI: 10.1016/j.gep.2014.05.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression pattern and first functional characterization of riok-1 in Caenorhabditis elegans.PMID 24929033Read ↗

The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction.Semantic proximity Read ↗

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read ↗

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

Parallel Rap1>RalGEF>Ral and Ras signals sculpt the <i>C. elegans</i> nervous systemSemantic proximity Read ↗

Transcriptional control of cell-cycle quiescence during C. elegans development.Semantic proximity Read ↗

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.Semantic proximity Read ↗

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

Multiple Functions and Dynamic Activation of MPK-1 Extracellular Signal-Regulated Kinase Signaling in<i>Caenorhabditis elegans</i>Germline DevelopmentSemantic proximity Read ↗

Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling.Semantic proximity Read ↗

Caenorhabditis elegans SOS-1 is necessary for multiple RAS-mediated developmental signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.