[Mechanism of carcinogenesis by germline mutation of protooncogene in hereditary tumors].

Article

[Mechanism of carcinogenesis by germline mutation of protooncogene in hereditary tumors].

Nihon rinsho. Japanese journal of clinical medicine - 1 Jun 2000

Miyaki M

Abstract excerpt

Germline mutations in one of two alleles of c-ret, c-met and c-kit protooncogenes have been revealed to be the causes of three autosomal dominant hereditary tumors; multiple endocrine neoplasia type 2(MEN2), hereditary papillary renal cell carcinoma (HPRCC), and familial gastrointestinal stromal tumor(FGIST), respectively. Patients with MEN2A have missense mutations at extracellular cysteine rich domain of c-ret,...

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