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Article

WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin Polymerization

23 May 2013

Abstract excerpt

Nck links phosphotyrosine-based signaling to Arp2/3-dependent actin polymerization during many different cellular processes as well as actin-based motility of enteropathogenic Escherichia coli (EPEC), vaccinia, and other vertebrate poxviruses by interacting with N-WASP/WASP. Nck also binds WASP-interacting protein (WIP), which inhibits the ability of N-WASP to activate the Arp2/3 complex until it receives an...

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Identifiers

PMID: 23707428
DOI: 10.1016/j.cub.2013.04.051

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WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin PolymerizationPMID 23707428Read ↗

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.Semantic proximity Read ↗

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WIP regulates N-WASP-mediated actin polymerization and filopodium formation.Semantic proximity Read ↗

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A reciprocal interdependence between Nck and PI(4,5)P(2) promotes localized N-WASp-mediated actin polymerization in living cells.Semantic proximity Read ↗

WIP and WICH/WIRE co-ordinately control invadopodium formation and maturation in human breast cancer cell invasionSemantic proximity Read ↗

Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP ComplexSemantic proximity Read ↗

A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeletonSemantic proximity Read ↗

Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL and NCK1Semantic proximity Read ↗

Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility.Semantic proximity Read ↗

WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1αSemantic proximity Read ↗

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.Semantic proximity Read ↗

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