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Article

Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex.

Science signaling - 24 Jun 2014

Fried Sophia, Reicher Barak, Pauker Maor H, Eliyahu Shani, Matalon Omri, Noy Elad, Chill Jordan, Barda-Saad Mira

Abstract excerpt

Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeletal machinery. Binding of WASp-interacting protein (WIP) to WASp modulates WASp activity and protects it from degradation. Formation of the WIP-WASp complex is crucial for the adaptive immune response. We found that WIP and WASp interacted in cells through two distinct molecular interfaces. One interaction occurred between the...

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PMID: 24962707
DOI: 10.1126/scisignal.2005198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Triple-color FRET analysis reveals conformational changes in the WIP-WASp actin-regulating complex.PMID 24962707Read ↗

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