Regulation and dysregulation at a critical hematopoietic junction: The human WASP-WIP complex.

Abstract excerpt

The complex formed between Wiskott-Aldrich syndrome protein (WASP) and WASP-Interacting Protein (WIP) is a potent regulator of cytoskeletal changes in hematopoietic cells. Mutations in the WASP N-terminal domain cause the primary immunodeficiencies Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). Using NMR we determine the structure of the WASP/WIP complex and provide a first molecular view of...

Topics

• Humans
• Wiskott-Aldrich Syndrome Protein
• Wiskott-Aldrich Syndrome
• Cytoskeletal Proteins
• Mutation
• Models, Molecular