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The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)

28 Feb 2012

Abstract excerpt

Enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC) are diarrheagenic pathogens that colonize the gut mucosa via attaching-and-effacing lesion formation. EPEC and EHEC utilize a type III secretion system (T3SS) to translocate effector proteins that subvert host cell signalling to sustain colonization and multiplication. EspH, a T3SS effector that modulates actin dynamics, was implicated in...

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PMID: 22372637
DOI: 10.1111/j.1462-5822.2012.01778.x

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Research trail→

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The enteropathogenic E. coli effector EspH promotes actin pedestal formation and elongation via WASP-interacting protein (WIP)PMID 22372637Read ↗

EspFU is a translocated EHEC effector that interacts with Tir and N-WASP and promotes Nck-independent actin assembly.Semantic proximity Read ↗

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WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin PolymerizationSemantic proximity Read ↗

Dissecting the role of the Tir:Nck and Tir:IRTKS/IRSp53 signalling pathways <i>in vivo</i>Semantic proximity Read ↗

Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.Semantic proximity Read ↗

Attaching-and-Effacing Pathogens Exploit Junction Regulatory Activities of N-WASP and SNX9 to Disrupt the Intestinal BarrierSemantic proximity Read ↗

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.Semantic proximity Read ↗

CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB.Semantic proximity Read ↗

EspF<sub>U</sub>, a type III-translocated effector of actin assembly, fosters epithelial association and late-stage intestinal colonization by E. coli O157:H7Semantic proximity Read ↗

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elementsSemantic proximity Read ↗

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