Article
WIP regulates N-WASP-mediated actin polymerization and filopodium formation.
Nature cell biology - 1 May 2001
Martinez-Quiles N, Rohatgi R, Antón I M, Medina M, Saville S P, Miki H, Yamaguchi H, Takenawa T, Hartwig J H, Geha R S, Ramesh N
Abstract excerpt
Induction of filopodia is dependent on activation of the small GTPase Cdc42 and on neural Wiskott-Aldrich-syndrome protein (N-WASP). Here we show that WASP-interacting protein (WIP) interacts directly with N-WASP and actin. WIP retards N-WASP/Cdc42-activated actin polymerization mediated by the Arp2/3 complex, and stabilizes actin filaments. Microinjection of WIP into NIH 3T3 fibroblasts induces filopodia; this...
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