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Article

New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.

ACS chemical biology - 19 Jan 2018

Halle-Bikovski Adi, Fried Sophia, Rozentur-Shkop Eva, Biber Guy, Shaked Hadassa, Joseph Noah, Barda-Saad Mira, Chill Jordan H

Abstract excerpt

Wiskott-Aldrich syndrome protein (WASp) is exclusively expressed in hematopoietic cells and responsible for actin-dependent processes, including cellular activation, migration, and invasiveness. The C-terminal domain of WASp-Interacting Protein (WIP) binds to WASp and regulates its activity by shielding it from degradation in a phosphorylation dependent manner as we previously demonstrated. Mutations in the...

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PMID: 29215267
DOI: 10.1021/acschembio.7b00486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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New Structural Insights into Formation of the Key Actin Regulating WIP-WASp Complex Determined by NMR and Molecular Imaging.PMID 29215267Read ↗

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