Article
APC truncation and increased beta-catenin levels in a human breast cancer cell line.
Carcinogenesis - 1 Jul 2000
Schlosshauer P W, Brown S A, Eisinger K, Yan Q, Guglielminetti E R, Parsons R, Ellenson L H, Kitajewski J
Abstract excerpt
Mutations in the Adenomatous Polyposis Coli (APC) tumor suppressor gene or the beta-catenin gene are present in most colon cancers and less frequently in other tumor types. In this study, we screened 24 human breast cancer cell lines and three immortalized human breast epithelial cell lines for alterations in beta- and gamma-catenin and APC by western blotting, protein truncation assay and DNA sequence analysis....
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