Article
Conformations of the rhodopsin third cytoplasmic loop grafted onto bacteriorhodopsin.
Structure (London, England : 1993) - 15 Jun 2000
Heymann J B, Pfeiffer M, Hildebrandt V, Kaback H R, Fotiadis D, Groot B, Engel A, Oesterhelt D, Müller D J
Abstract excerpt
BACKGROUND: The third cytoplasmic loop of rhodopsin (Rho EF) is important in signal transduction from the retinal in rhodopsin to its G protein, transducin. This loop also interacts with rhodopsin kinase, which phosphorylates light-activated rhodopsin, and arrestin, which displaces transducin from light-activated phosphorylated rhodopsin. RESULTS: We replaced eight residues of the EF loop of bacteriorhodopsin...
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