Mapping of the amino acids in the cytoplasmic loop connecting helices C and D in rhodopsin. Chemical reactivity in the dark state following single cysteine replacements.

Abstract excerpt

The cytoplasmic loop connecting helices C and D in rhodopsin is a part of the region involved in protein-protein interactions during signal transduction. To probe the structure of the CD loop, we have replaced, one at a time, the amino acids 136-150 by cysteine residues. The cysteine substitution mutants contained only the introduced single reactive cysteines and were prepared from a base opsin mutant that...

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