Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural insights into the mechanism of rhodopsin phosphodiesterase.

Nature communications - 5 Nov 2020

Ikuta Tatsuya, Shihoya Wataru, Sugiura Masahiro, Yoshida Kazuho, Watari Masahito, Tokano Takaya, Yamashita Keitaro, Katayama Kota, Tsunoda Satoshi P, Uchihashi Takayuki, Kandori Hideki, Nureki Osamu

Abstract excerpt

Rhodopsin phosphodiesterase (Rh-PDE) is an enzyme rhodopsin belonging to a recently discovered class of microbial rhodopsins with light-dependent enzymatic activity. Rh-PDE consists of the N-terminal rhodopsin domain and C-terminal phosphodiesterase (PDE) domain, connected by 76-residue linker, and hydrolyzes both cAMP and cGMP in a light-dependent manner. Thus, Rh-PDE has potential for the optogenetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HEK293 Cells
Share to Models, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphoric Diester Hydrolases

Share to Protein Domains

Share to Rhodopsin

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 33154353
DOI: 10.1038/s41467-020-19376-7
PMCID: PMC7644710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural insights into the mechanism of rhodopsin phosphodiesterase.PMID 33154353Read ↗

Rhodopsin: structure, function, and genetics.Semantic proximity Read ↗

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.Semantic proximity Read ↗

The eye photoreceptor protein rhodopsin. Structural implications for retinal disease.Semantic proximity Read ↗

[Biophysical and Biochemical Research of Animal Rhodopsins].Semantic proximity Read ↗

A microbial rhodopsin with a unique retinal composition shows both sensory rhodopsin II and bacteriorhodopsin-like properties.Semantic proximity Read ↗

Constitutively active rhodopsin and retinal disease.Semantic proximity Read ↗

Rhodopsin homeostasis and retinal degeneration: lessons from the fly.Semantic proximity Read ↗

Drosophila melanogaster rhodopsin Rh7 is a UV-to-visible light sensor with an extraordinarily broad absorption spectrum.Semantic proximity Read ↗

The high-light-sensitivity mechanism and optogenetic properties of the bacteriorhodopsin-like channelrhodopsin GtCCR4.Semantic proximity Read ↗

Atomistic insights into rhodopsin activation from a dynamic model.Semantic proximity Read ↗

The evolutionary relationship between microbial rhodopsins and metazoan rhodopsins.Semantic proximity Read ↗

The molecular architecture of photoreceptor phosphodiesterase 6 (PDE6) with activated G protein elucidates the mechanism of visual excitation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.