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Article

Downregulation of proapoptotic proteins Bax and Bcl-X(S) in p53 overexpressing hepatocellular carcinomas.

Biochemical and biophysical research communications - 24 Jun 2000

Beerheide W, Tan Y J, Teng E, Ting A E, Jedpiyawongse A, Srivatanakul P

Abstract excerpt

As the occurrence of structural p53 mutations in hepatocellular carcinoma (HCC) in Thailand was previously reported to be much lower than that found in other high-incidence HCC areas, we analyzed 16 HCC samples from Thailand to determine the expression and functionality of p53 protein. We observed the overexpression of p53 protein in 69% of HCC, despite the prevalence of the wild-type p53 gene. However, the...

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PMID: 10873563
DOI: 10.1006/bbrc.2000.2891

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