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Article

Expressional and mutational analysis of pro-apoptotic Bcl-2 member PUMA in hepatocellular carcinomas.

Digestive diseases and sciences - 1 May 2008

Ahn Chang H, Jeong Eun G, Kim Sung S, Lee Jong W, Lee Sung H, Kim Sung H, Kim Min S, Yoo Nam J, Lee Sug Hyung

Abstract excerpt

Deregulation of apoptosis is involved in mechanisms of cancer development. PUMA is a pro-apoptotic member of the Bcl-2 family and mediates p53-dependent and -independent apoptosis. The aim of this study was to investigate whether alterations of PUMA protein expression and somatic mutations of PUMA gene are characteristics of human hepatocellular carcinoma (HCC). We analyzed expression of PUMA protein in 20 HCCs...

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Share to Apoptosis Regulatory Proteins
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, bcl-2

Share to Immunohistochemistry

Share to Liver Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Proteins

Source

Identifiers

PMID: 17934815
DOI: 10.1007/s10620-007-9987-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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