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Article

Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells.

PloS one - 1 Jan 2011

Hung Jui-Hsiang, Teng Yen-Ni, Wang Lily Hui-Ching, Su Ih-Jen, Wang Clay C C, Huang Wenya, Lee Kuan-Han, Lu Kuan-Ying, Wang Lyu-Han

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with poor prognosis due to resistance to conventional chemotherapy and limited efficacy of radiotherapy. Our previous studies have indicated that expression of Hepatitis B virus pre-S2 large mutant surface...

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Share to Antimetabolites, Antineoplastic
Share to Caspase 3
Share to Endoplasmic Reticulum Chaperone BiP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorouracil

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Share to Proto-Oncogene Proteins c-bcl-2

Source

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Identifiers

PMID: 22216150
DOI: 10.1371/journal.pone.0028977
PMCID: PMC3245229

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22216150-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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