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Article

Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 12 Jan 2011

McKenna William L, Betancourt Jennifer, Larkin Kathryn A, Abrams Benjamin, Guo Chao, Rubenstein John L R, Chen Bin

Abstract excerpt

The molecular mechanisms regulating fate divergence of closely related, but distinct, layer 6 corticothalamic and layer 5 subcerebral projection neurons are largely unknown. We present evidence for central transcriptional mechanisms that regulate fate specification of corticothalamic (layer 6) and subcerebral (layer 5) projection neurons. We found that TBR1 promotes the identity of corticothalamic neurons and...

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Source

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Identifiers

PMID: 21228164
DOI: 10.1523/JNEUROSCI.4131-10.2011
PMCID: PMC3276402

Genes

TBR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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