Article
Tbr1 regulates differentiation of the preplate and layer 6.
Neuron - 1 Feb 2001
Hevner R F, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, Bulfone A, Goffinet A M, Campagnoni A T, Rubenstein J L
Abstract excerpt
During corticogenesis, early-born neurons of the preplate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting...
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