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Article

Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit.

Molecular and cellular biology - 1 Feb 2002

Moriarty Tara J, Huard Sylvain, Dupuis Sophie, Autexier Chantal

Abstract excerpt

Functional human telomerase complexes are minimally composed of the human telomerase RNA (hTR) and a catalytic subunit (human telomerase reverse transcriptase [hTERT]) containing reverse transcriptase (RT)-like motifs. The N terminus of TERT proteins is unique to the telomerase family and has been implicated in catalysis, telomerase RNA binding, and telomerase multimerization, and conserved motifs have been...

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Identifiers

PMID: 11809815
DOI: 10.1128/MCB.22.4.1253-1265.2002
PMCID: PMC134651

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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