Article
Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis.
The American journal of pathology - 1 Dec 2001
Young J, Simms L A, Biden K G, Wynter C, Whitehall V, Karamatic R, George J, Goldblatt J, Walpole I, Robin S A, Borten M M, Stitz R, Searle J, McKeone D, Fraser L, Purdie D R, Podger K, Price R, Buttenshaw R, Walsh M D, Barker M, Leggett B A, Jass J R
Abstract excerpt
High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic colorectal cancers and in most cancers presenting in the inherited condition hereditary nonpolyposis colorectal cancer (HNPCC). Distinction between these categories of MSI-H cancer is of clinical importance and the aim of this study was to assess clinical, pathological, and molecular features that might be discriminatory. One...
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