Article
Genetic susceptibility to tuberculosis in Africans: a genome-wide scan.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2000
Bellamy R, Beyers N, McAdam K P, Ruwende C, Gie R, Samaai P, Bester D, Meyer M, Corrah T, Collin M, Camidge D R, Wilkinson D, Hoal-Van Helden E, Whittle H C, Amos W, van Helden P, Hill A V
Abstract excerpt
Human genetic variation is an important determinant of the outcome of infection with Mycobacterium tuberculosis. We have conducted a two-stage genome-wide linkage study to search for regions of the human genome containing tuberculosis-susceptibility genes. This approach uses sibpair families that contain two full siblings who have both been affected by clinical tuberculosis. For any chromosomal region containing...
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