Article
Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis.
Tuberculosis (Edinburgh, Scotland) - 1 Mar 2010
Möller Marlo, Hoal Eileen G
Abstract excerpt
The evidence for a human genetic component in susceptibility to tuberculosis (TB) is incontrovertible. Quite apart from studies of rare disease events illustrating the importance of key genes in humans and animals, TB at the population level is also influenced by the genetics of the host. Heritability of disease concordance and immune responses to mycobacterial antigens has been clearly shown, and ranges up to...
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