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Cardiovascular Responses to the Isoprostanes iPF<sub>2α</sub>-III and iPE<sub>2</sub>-III Are Mediated via the Thromboxane A<sub>2</sub>Receptor In Vivo

20 Jun 2000

Abstract excerpt

BACKGROUND: Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate platelet function and vascular tone. Although these effects are blocked by antagonists of the...

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PMID: 10859290
DOI: 10.1161/01.cir.101.24.2833

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