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Article

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis.

Nature cell biology - 1 Jun 2000

Matsuyama S, Llopis J, Deveraux Q L, Tsien R Y, Reed J C

Abstract excerpt

Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive green fluorescent protein (GFP), that mitochondria-dependent apoptotic stimuli (such as Bax, staurosporine and ultraviolet irradiation) induce rapid, Bcl-2-inhibitable mitochondrial alkalinization and cytosol acidification, followed by cytC release, caspase activation and mitochondrial...

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Identifiers

PMID: 10854321
DOI: 10.1038/35014006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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