Article
Granzyme B induces BID-mediated cytochrome c release and mitochondrial permeability transition.
The Journal of biological chemistry - 9 Mar 2001
Alimonti J B, Shi L, Baijal P K, Greenberg A H
Abstract excerpt
Many cell death pathways converge at the mitochondria to induce release of apoptogenic proteins and permeability transition, resulting in the activation of effector caspases responsible for the biochemical and morphological alterations of apoptosis. The death receptor pathway has been described as a triphasic process initiated by the activation of apical caspases, a mitochondrial phase, and then the final phase...
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