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Article

Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-Ig<sup>TM</sup>) molecules

1 Aug 2009

Abstract excerpt

Signal transduction through the interleukin-1 receptor (IL-1R) pathway mediates a strong pro-inflammatory response, which contributes to a number of human diseases such as rheumatoid arthritis. Within the IL-1 family, IL-1alpha and IL-1beta are both agonistic ligands for IL-1R, whereas IL-1 receptor antagonist (IL-1ra) is an endogenous antagonist that binds to IL-R, but does not signal. Therefore, the ideal...

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Identifiers

PMID: 20068402
DOI: 10.4161/mabs.1.4.8755

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