Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.

Development (Cambridge, England) - 1 Jul 2000

Cammas F, Mark M, Dollé P, Dierich A, Chambon P, Losson R

Abstract excerpt

TIF1beta, a member of the transcriptional intermediary factor 1 family, has been reported to function as a corepressor for the large class of KRAB domain-containing zinc finger proteins of the Krüppel type. To address the biological function of TIF1beta, we have generated TIF1beta-deficient mice by gene disruption. TIF1beta protein was detected in wild-type but not TIF1beta(-/-) blastocysts. Homozygous mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to Brachyury Protein
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Proteins

Share to Fluorescent Antibody Technique

Share to Gastrula

Share to T-Box Domain Proteins

Share to Zinc Fingers

Source

Identifiers

PMID: 10851139
DOI: 10.1242/dev.127.13.2955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development.PMID 10851139Read ↗

Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation.Semantic proximity Read ↗

Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouseSemantic proximity Read ↗

Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.Semantic proximity Read ↗

The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis.Semantic proximity Read ↗

Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development.Semantic proximity Read ↗

The TIF1β-HP1 system maintains transcriptional integrity of hematopoietic stem cells.Semantic proximity Read ↗

Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.Semantic proximity Read ↗

A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.Semantic proximity Read ↗

Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis.Semantic proximity Read ↗

Epigenetic regulation of unique genes and repetitive elements by the KRAB zinc finger protein ZFP57Semantic proximity Read ↗

Requirement for the murine zinc finger protein ZFR in perigastrulation growth and survival.Semantic proximity Read ↗

Proteins involved in establishment and maintenance of imprinted methylation marksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.