Article
An RNA Aptamer Inhibits a Mutation-Induced Inactivating Misfolding of a Serpin.
Cell chemical biology - 23 Jun 2016
Madsen Jeppe B, Andersen Lisbeth M, Dupont Daniel M, Trelle Morten B, Johansen Jesper S, Jensen Jan K, Jørgensen Thomas J D, Andreasen Peter A
Abstract excerpt
Most serpins are fast and specific inhibitors of extracellular serine proteases controlling biological processes such as blood coagulation, fibrinolysis, tissue remodeling, and inflammation. The inhibitory activity of serpins is based on a conserved metastable structure and their conversion to a more stable state during reaction with the target protease. However, the metastable state also makes serpins vulnerable...
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