Article
Mannose-binding lectin exon 1 and promoter polymorphisms in tuberculosis disease in a Mediterranean area.
International journal of immunogenetics - 1 Aug 2014
García-Gasalla M, Milá Llambí J, Losada-López I, Cifuentes-Luna C, Fernández-Baca V, Pareja-Bezares A, Mir-Villadrich I, Payeras-Cifré A
Abstract excerpt
Mannose-binding lectin (MBL) is a serum protein that activates the complement and mediates phagocytosis. MBL levels and MBL2 genotype may impact upon host susceptibility to tuberculosis (TB) disease but evidence to date has been conflicting. MBL2 exon 1 and promoter genotyping and serum MBL concentrations were determined in 79 patients with active tuberculosis (58 pulmonary TB and 21 extrapulmonary or miliary TB)...
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