Article
Expression of receptor for advanced glycation end products in sarcoid granulomas.
American journal of respiratory and critical care medicine - 1 Mar 2007
Campo Ilaria, Morbini Patrizia, Zorzetto Michele, Tinelli Carmine, Brunetta Enrico, Villa Chiara, Bombieri Cristina, Cuccia Mariaclara, Agostini Carlo, Bozzi Valeria, Facoetti Angelica, Ferrarotti Ilaria, Mazzola Paola, Scabini Roberta, Semenzato Gianpietro, Pignatti Pier Franco, Pozzi Ernesto, Luisetti Maurizio
Abstract excerpt
RATIONALE: The receptor for advanced glycation end products (RAGE) engages a number of ligands implicated in inflammatory processes. The RAGE coding gene maps to the 6p21.32 region, close to the genes DRB1 and BTNL2, which are associated with sarcoidosis. OBJECTIVES: We investigated a possible implication of RAGE in sarcoid granulomas. METHODS: RAGE and major ligands (N-epsilon-carboxy-methyl-lysine [CML],...
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