Article
Genetic variation in GREM1 is a risk factor for fibrosis in pulmonary sarcoidosis.
Tissue antigens - 1 Feb 2011
Heron M, van Moorsel C H M, Grutters J C, Huizinga T W J, van der Helm-van Mil A H M, Nagtegaal M M, Ruven H J T, van den Bosch J M M
Abstract excerpt
Sarcoidosis is a granulomatous systemic disorder most often affecting the lung. Pulmonary fibrosis develops in approximately 10%-15% of patients with sarcoidosis. The human gene GREM1 encodes gremlin, a member of the bone morphogenetic protein antagonist family. Bone morphogenetic proteins are essential for the maintenance of tissue homeostasis and regeneration after injury. We examined associations between...
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