Article
The role of Cdh1p in maintaining genomic stability in budding yeast.
Genetics - 1 Oct 2003
Ross Karen E, Cohen-Fix Orna
Abstract excerpt
Cdh1p, a substrate specificity factor for the cell cycle-regulated ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C), promotes exit from mitosis by directing the degradation of a number of proteins, including the mitotic cyclins. Here we present evidence that Cdh1p activity at the M/G(1) transition is important not only for mitotic exit but also for high-fidelity chromosome segregation in the...
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