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Article

A downstream element in the human β-globin promoter: Evidence of extended sequence-specific transcription factor IID contacts

6 Jun 2000

Abstract excerpt

We describe here the identification and characterization of a functional downstream element in the human adult beta-globin promoter. The existence of this element was indicated by two mutations at +22 and +33 downstream of the beta-globin transcriptional start site in humans with beta-thalassemia. In vitro transcriptional analysis of these mutants, plus a third at +13, indicates that all three decrease...

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PMID: 10840054
DOI: 10.1073/pnas.120181197

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