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Article

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.

Nature medicine - 1 Sept 1999

Schuetz J D, Connelly M C, Sun D, Paibir S G, Flynn P M, Srinivas R V, Kumar A, Fridland A

Abstract excerpt

Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common component of highly active anti-retroviral therapy (HAART) (ref. 1). Six reverse transcriptase inhibitors have been approved for human use: azidothymidine; 2'3'-dideoxycytidine; 2'3'-dideoxyinosine; 2', 3'-didehydro-3'deoxythymidine; 2',3'-dideoxy-3'-thiacytidine; and...

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Identifiers

PMID: 10470083
DOI: 10.1038/12487

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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