Article
Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrins.
The Journal of biological chemistry - 20 Mar 1998
Bazzoni G, Ma L, Blue M L, Hemler M E
Abstract excerpt
Here we show striking differences in conformational regulation among beta1 integrins. Upon manganese stimulation, a beta1 epitope defined by monoclonal antibody (mAb) 9EG7 was induced strongly (on alpha4beta1), moderately (on alpha5beta1), weakly (on alpha2beta1), or was scarcely detectable (on a...
Topics
- Amino Acid Sequence
- Cations, Divalent
- Cell Line
- Chelating Agents
- Cytoplasm
- Epitopes
- Humans
- Integrin beta1
- Intercellular Signaling Peptides and Proteins
- Ligands
- Manganese
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Conformation
- Sequence Homology, Amino Acid