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Article

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.

The Journal of biological chemistry - 31 May 2002

Mould A Paul, Askari Janet A, Barton Stephanie, Kline Adam D, McEwan Paul A, Craig Susan E, Humphries Martin J

Abstract excerpt

The ligand-binding region of integrin beta subunits contains a von Willebrand factor type A-domain: an alpha/beta "Rossmann" fold containing a metal ion-dependent adhesion site (MIDAS) on its top face. Although there is evidence to suggest that the betaA-domain undergoes changes in tertiary structure during receptor activation, the identity of the secondary structure elements that change position is unknown. The...

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Identifiers

PMID: 11893752
DOI: 10.1074/jbc.M201571200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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