Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer.

doi:10.1111/j.1349-7006.2000.tb00974.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer.

Japanese journal of cancer research : Gann - 1 May 2000

Sato M, Sekido Y, Horio Y, Takahashi M, Saito H, Minna J D, Shimokata K, Hasegawa Y

Abstract excerpt

Mitotic checkpoint defects of the cell cycle have been implicated in the development of human cancers. Since hBUB1 and hBUBR1, whose products function in the spindle checkpoint pathway, have been shown to be mutated in a subset of colon cancers with chromosomal instability, we investigated the contribution of these genes to lung cancer development. One hundred and two lung cancer (50 small cell lung cancers and...

Topics

Carcinoma, Non-Small-Cell Lung
Carcinoma, Small Cell
Cell Cycle Proteins
Down-Regulation
Lung Neoplasms
Mesothelioma
Mutation
Neoplasm Proteins
Polymorphism, Single-Stranded Conformational
Protein Kinases
Protein Serine-Threonine Kinases
Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 10835495
DOI: 10.1111/j.1349-7006.2000.tb00974.x
PMCID: PMC5926378

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics