Article
Mutation and expression analysis of human BUB1 and BUB1B in aneuploid breast cancer cell lines.
Cancer letters - 1 May 2000
Myrie K A, Percy M J, Azim J N, Neeley C K, Petty E M
Abstract excerpt
Genetic instability is a hallmark feature of breast, colorectal and other types of cancers. One type characterized by chromosomal instability is thought to be important in the pathogenesis of many solid tumors displaying aneuploidy. Two related protein kinases and homologues of the yeast checkpoint genes, hBUB1 and hBUB1B, have been implicated in the pathogenesis of colorectal cancers. Mutations in hBUB1 have...
Topics
- Alleles
- Blotting, Northern
- Blotting, Southern
- Breast Neoplasms
- Codon
- DNA Mutational Analysis
- Female
- Humans
- Mutation
- Phenotype
- Ploidies
- Polymorphism, Genetic