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Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer.

Genes, chromosomes & cancer - 1 Nov 2000

Gemma A, Seike M, Seike Y, Uematsu K, Hibino S, Kurimoto F, Yoshimura A, Shibuya M, Harris C C, Kudoh S

Abstract excerpt

Mutations in mitotic checkpoint genes have been detected in several human cancers, and these cancers exhibit chromosomal instability. Aneuploid stem cells seem to result from chromosomal instability and have been reported in many lung cancers. To determine whether alteration of mitotic checkpoint regulators is involved in carcinogenesis and tumor progression in primary lung cancer, we screened the genomic DNA...

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Identifiers

PMID: 10992296
DOI: 10.1002/1098-2264(2000)9999:9999<::aid-gcc1027>3.0.co;2-g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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