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Article

Bayesian fine-scale mapping of disease loci, by hidden Markov models.

American journal of human genetics - 1 Jul 2000

Morris A P, Whittaker J C, Balding D J

Abstract excerpt

We present a new multilocus method for the fine-scale mapping of genes contributing to human diseases. The method is designed for use with multiple biallelic markers-in particular, single-nucleotide polymorphisms for which high-density genetic maps will soon be available. We model disease-marker association in a candidate region via a hidden Markov process and allow for correlation between linked marker loci....

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Identifiers

PMID: 10835299
DOI: 10.1086/302956
PMCID: PMC1287074

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