Article
Functional role of RXRs and PPARgamma in mature adipocytes.
Prostaglandins, leukotrienes, and essential fatty acids - 1 Jul 2005
Metzger D, Imai T, Jiang M, Takukawa R, Desvergne B, Wahli W, Chambon P
Abstract excerpt
The peroxisome proliferator-activated receptor gamma (PPARgamma) is abundantly expressed in adipocytes, and plays an important role in adipocyte differentiation and fat accretion. It is a heterodimeric partner of the retinoid X receptors alpha, beta and gamma, which are also expressed in the adipose tissue. As lethality of PPARgamma(-/-) and RXRalpha(-/-) mouse fetuses precluded the analysis of PPARgamma and...
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